Alpha Lipoic Acid

The Basics

Alpha lipoic acid is a potent, versatile antioxidant that helps to fend off inflammation, balance blood sugar and protect skin collagen. It boosts the effectiveness of other antioxidants in your body, promotes nerve health, helps remove heavy metals from the body and purify the liver.

Often used in skincare products to enhance the skin and help combat signs of cellular aging.

How to take it

Take 2 capsules per day or as directed by your health care practitioner.

Contents

60 capsules

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Product Ingredients

ALPHA LIPOIC ACID

Directions

As a dietary supplement, take 2 capsules daily between meals or as directed by your health care practitioner.

Formulated to exclude gluten, dairy, corn, yeast, soy.

Store tightly closed in a cool, dry, dark place. Natural color, size and shape may vary between lots.

Manufactured in an NSF certified GMP registered facility.

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Research

ALPHA LIPOIC ACID

Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?
Gianturco V, Bellomo A, D'Ottavio E, Formosa V, Iori A, Mancinella M, Troisi G, Marigliano V.
Arch Gerontol Geriatr. 2009;49 Suppl 1:129-33.
PMID:19836626[PubMed - indexed for MEDLINE]
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Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells.
Choi SY, Yu JH, Kim H.
Ann N Y Acad Sci. 2009 Aug;1171:149-55.
PMID:19723049[PubMed - indexed for MEDLINE]
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Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats.
Lee YM, Bae SY, Won NH, Pyo HJ, Kwon YJ.
Nephron Exp Nephrol. 2009;113(4):e104-12. Epub 2009 Aug 27.
PMID:19713707[PubMed - indexed for MEDLINE]
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Modulatory role of lipoic acid on lipopolysaccharide-induced oxidative stress in adult rat Sertoli cells in vitro.
Aly HA, Lightfoot DA, El-Shemy HA.
Chem Biol Interact. 2009 Dec 10;182(2-3):112-8. Epub 2009 Aug 21.
PMID:19699728[PubMed - indexed for MEDLINE]
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Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM.
Biochim Biophys Acta. 2009 Oct;1790(10):1149-60. Epub 2009 Aug 4. Review.
PMID:19664690[PubMed - indexed for MEDLINE]
Free PMC Article
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Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.
Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM.
J Neurosci. 2009 Jul 29;29(30):9500-9.
PMID:19641113[PubMed - indexed for MEDLINE]
Free PMC Article
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A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.
Poh ZX, Goh KP.
Endocr Metab Immune Disord Drug Targets. 2009 Dec;9(4):392-8. Review.
PMID:19601918[PubMed - indexed for MEDLINE]
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Taurine supplementation enhances nutrient-induced insulin secretion in pancreatic mice islets.
Ribeiro RA, Bonfleur ML, Amaral AG, Vanzela EC, Rocco SA, Boschero AC, Carneiro EM.
Diabetes Metab Res Rev. 2009 May;25(4):370-9.
PMID:19405082[PubMed - indexed for MEDLINE]
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Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus.
Gavrovskaya LK, Ryzhova OV, Safonova AF, Matveev AK, Sapronov NS.
Bull Exp Biol Med. 2008 Aug;146(2):226-8. English, Russian.
PMID:19145324[PubMed - indexed for MEDLINE]
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Alpha-lipoic acid supplementation and diabetes.
Singh U, Jialal I.
Nutr Rev. 2008 Nov;66(11):646-57. Review.
PMID:19019027[PubMed - indexed for MEDLINE]
Free PMC Article
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Taurine supplementation modulates glucose homeostasis and islet function.
Carneiro EM, Latorraca MQ, Araujo E, Beltrá M, Oliveras MJ, Navarro M, Berná G, Bedoya FJ, Velloso LA, Soria B, Martín F.
J Nutr Biochem. 2009 Jul;20(7):503-11. Epub 2008 Aug 15.
PMID:18708284[PubMed - indexed for MEDLINE]
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Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.
Maczurek A, Hager K, Kenklies M, Sharman M, Martins R, Engel J, Carlson DA, Münch G.
Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70. Epub 2008 Jul 4. Review.
PMID:18655815[PubMed - indexed for MEDLINE]
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Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Salinthone S, Yadav V, Bourdette DN, Carr DW.
Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):132-42. Review.
PMID:18537699[PubMed - indexed for MEDLINE]
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Effect of biotin treatment on hepatic gene expression in streptozotocin-induced diabetic rats.
Sugita Y, Shirakawa H, Sugimoto R, Furukawa Y, Komai M.
Biosci Biotechnol Biochem. 2008 May;72(5):1290-8. Epub 2008 May 7.
PMID:18460817[PubMed - indexed for MEDLINE]
Free Article
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Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.
Sena CM, Nunes E, Louro T, Proença T, Fernandes R, Boarder MR, Seiça RM.
Br J Pharmacol. 2008 Mar;153(5):894-906. Epub 2007 Oct 1.
PMID:17906683[PubMed - indexed for MEDLINE]
Free PMC Article
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Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.
Holmquist L, Stuchbury G, Berbaum K, Muscat S, Young S, Hager K, Engel J, Münch G.
Pharmacol Ther. 2007 Jan;113(1):154-64. Epub 2006 Sep 20. Review.
PMID:16989905[PubMed - indexed for MEDLINE]
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Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects with hypertriglyceridemia.
Revilla-Monsalve C, Zendejas-Ruiz I, Islas-Andrade S, Báez-Saldaña A, Palomino-Garibay MA, Hernández-Quiróz PM, Fernandez-Mejia C.
Biomed Pharmacother. 2006 May;60(4):182-5. Epub 2006 Mar 31.
PMID:16677798[PubMed - indexed for MEDLINE]
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Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review.
Ziegler D.
Treat Endocrinol. 2004;3(3):173-89. Review.
PMID:16026113[PubMed - indexed for MEDLINE]
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Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells.
Byun CH, Koh JM, Kim DK, Park SI, Lee KU, Kim GS.
J Bone Miner Res. 2005 Jul;20(7):1125-35. Epub 2005 Mar 7.
PMID:15940365[PubMed - indexed for MEDLINE]
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Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).
Tankova T, Koev D, Dakovska L.
Rom J Intern Med. 2004;42(2):457-64.
PMID:15529636[PubMed - indexed for MEDLINE]
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